The genus is distinguished on the basis of genetic characters.
No surface morphology is visible by EM.
Physicochemical and physical properties
Virions are stable at acid pH. Buoyant density in CsCl is 1.33 g cm-3. Empty capsids are often observed in virus preparations.
Genome (Zell et al., 2001, Buitrago et al., 2010, Boros et al., 2012b, Yang et al., 2018, Oba et al., 2018): >7,110 nt (5′-proximal sequence missing) (5′-UTR: >335 nt; ORF: 6,600–6,711; 3′-UTR: 67 nt). Teschoviruses have a type IV IRES of about 290 nt which is functional in the absence of eIF-4G. The location of the cre is thought to be within the 2C region.
Genome organization and replication
The deduced polyprotein varies from 2,199–2,236 aa. The function of the leader polypeptide is unknown. 2A is a short polypeptide with an NPG↓P motif.
Clinical manifestations may include a polioencephalomyelitis (“Teschen/Talfan disease”, also known as teschovirus encephalomyelitis), which may vary in severity. The viruses have been associated with a number of disease syndromes, including reproductive and gastrointestinal disorders. Domestic pigs and wild boars are the only known hosts. Natural inter-species recombination has been described. Nineteen genetic types are distinguished by means of phylogenetic analysis (Teschovirus A: teschovirus A1 to -A14, Teschovirus B: teschovirus B1 to -B3; recombinant viruses: teschovirus A15CP-BPol, teschovirus A16CP-BPol).
Porcine teschoviruses are divided into 13 types (PTV-1 to -13) which are distinct in cross-neutralization tests (where tested).
Derivation of names
Teschovirus: from Teschen disease; named after the Moravian-Silesian town Teschen (now Těšín at the Czech/Polish border.
Species demarcation criteria
Members of a species of the genus Teschovirus:
- are less than 20% divergent in polyprotein aa sequence
- are less than 30% divergent in P1 aa sequence
- are less than 10% divergent in 2C+3CD aa sequence
- share a common genome organization
- share a natural host range