Family: Picornaviridae

Genus: Rosavirus


Distinguishing features

The genus is distinguished on the basis of genetic characters. 



No details are available on the morphology of virions. 

Nucleic acid

Genome (Phan et al., 2011Lim et al., 2014Du et al., 2016Lau et al., 2016): c. 8,931 nt (5′-UTR: 504–721 nt; ORF: 7,410–7,449 nt; 3′-UTR: 712–946 nt). The 5′-UTR harbours a type II IRES. The 3′-UTR is the longest of picornaviruses. The location of the cre has not been identified.

Genome organization and replication

Genome layout:


The deduced polyprotein is of 2,468–2,491 aa. 2A has an H-box/NC motif. 


No virus has been isolated. Viral RNA was detected in faecal samples of humans and rodents [canyon mouse (Peromyscus crinitus), brown rat (Rattus norvegicus), black rat (R. rattus), Sikkim rat (R. andamanensis), chestnut white-bellied rat (Niviventer fulvescens)]. Eight genetic types are distinguished by means of phylogenetic analysis (Rosavirus A: 2 types; Rosavirus B: 2 types; Rosavirus C: 4 types).

Derivation of names

Rosavirus: from rodent stool-associated virus

Species demarcation criteria

Members of a species of genus Rosavirus:

  • share a common genome organization
  • are less than 30% divergent in the polyprotein aa sequence
  • are less than 30% divergent in the P1 aa sequence
  • are less than 25% divergent in the 2C + 3CD aa sequence