Resources: Arteriviridae

Sequence alignments:

Figure 3. Arteriviridae:

Concatenated alignment (FASTA format)

3CLpro alignment (FASTA format)

Authors: Arteriviridae

Margo A. Brinton*
Georgia State University
Department of Biology
PO Box 4010
Atlanta
GA 30303-4010
USA
E-mail: [email protected]

Anastasia A. Gulyaeva
Department of Medical Microbiology
Leiden University Medical Center
2300 RC Leiden
the Netherlands
E-mail: [email protected]

Subfamily: Zealarterivirinae

Genus: Kappaarterivirus

Distinguishing features

Kappaarterivirus wobum is the only species in the family. There is, however, considerable variability between available wobbly possum disease virus (WPDV) sequences isolated in New Zealand and Australia (70 to 80% identity at the amino acid level within the conserved RNA-directed RNA polymerase (RdRp) protein) and hence, these may be split into separate species in the future. 

Family: Arteriviridae

Subfamily: Zealarterivirinae

Subfamily: Variarterivirinae

Genus: Nuarterivirus

Distinguishing features

Members of this genus form a clade upon phylogenetic analysis (Figure 3. Arteriviridae). 

Virion

See discussion under family description. 

Subfamily: Variarterivirinae

Genus: Gammaarterivirus

Distinguishing features

Members of this genus infect mice and typically cause lifelong persistent infections without obvious symptoms. One isolate of lactate dehydrogenase-elevating virus (LDV C) has been associated with neurological disease in the C58 mouse strain. 

Virion

See discussion under family description. 

Subfamily: Variarterivirinae

Genus: Betaarterivirus

Distinguishing features

Betaarteriviruses infect pigs

Virion

See discussion under family description. 

Family: Arteriviridae

Subfamily: Variarterivirinae

Distinguishing features

Members of this subfamily form a clade upon phylogenetic analysis (Figure 3. Arteriviridae). They encode an nsp2 protein that is considerably larger than its counterparts in viruses of other subfamilies, mostly due to the hypervariable region flanked by PLP2 and TM1.  

Subfamily: Simarterivirinae

Genus: Zetaarterivirus

Distinguishing features

Kibale red colobus virus 1 (KRCV-1), a member of the only species in this genus. KRCV-1 infects Red colobus monkeys in Kibale National Park, Uganda, subclinically and persistently with high viral loads in the blood. 

Virion

See discussion under family description. 

Subfamily: Simarterivirinae

Genus: Thetaarterivirus

Distinguishing features

Mikumi yellow baboon virus 1 (MYBV-1) and Kafue kinda chacma baboon virus (KKCBV) infect wild baboons (genus Papio) subclinically.  

Virion

See discussion under family description.