These viruses are associated with fibropapillomas in their respective ungulate hosts. Trans-species transmission occurs, where it induces non-productive sarcoids. The E5 protein, located in the region between the early and late genes, has transforming properties.
See discussion under family description.
Members of this genus are typically found on the skin and oral mucosa of primates. Infections are usually asymptomatic. However, some infections cause cutaneous lesions in their host and are histologically distinguishable by intracytoplasmic inclusion bodies. The members of the species Gammapapillomavirus 6 do not contain an E6 ORF, but encode a putative E10 protein in the same location.
The papillomaviruses within the subfamily Firstpapillomavirinae are associated with amniote (reptile, bird, and mammalian) hosts. These viruses contain the core viral proteins (E1, E2, L1, and L2) and at least one additional accessory protein (E5, E6 or E7).
The exemplar isolate of the single species in this genus (the only genus in the Secondpapillomavirinae) was associated with skin lesions of fish, gilt-head (sea) bream (Sparus aurata), and has the smallest papillomavirus genome known. The genome consists of the core viral proteins (E1, E2, L1, and L2).
The exemplar isolate of the single species in the single genus in the Secondpapillomavirinae was isolated from a fish and has the smallest papillomavirus genome known. The genome consists of the core viral proteins (E1, E2, L1, and L2).
A summary of this ICTV Report chapter has been published as an ICTV Virus Taxonomy Profile article in the Journal of General Virology, and should be cited when referencing this online chapter as follows:
The Papillomavirus Episteme (PaVE; pave.niaid.nih.gov (Van Doorslaer et al. , 2017; Van Doorslaer et al. , 2013)) provides centralized access to a special edition of the journal ‘Virology’ (Lambert PF et al. , 2013). This special edition combined expert reviews of various papillomavirus-associated topics.
