Family: Mypoviridae

 

Jens H. Kuhn, Scott Adkins, Katherine Brown, Juan Carlos de la Torre, Michele Digiaro, Holly R. Hughes, Sandra Junglen, Amy J. Lambert, Piet Maes, Marco Marklewitz, Gustavo Palacios, Takahide Sasaya (笹谷孝英), Massimo Turina, and Yong-Zhen Zhang (张永振)

The citation for this ICTV Report chapter is the summary to be published as Kuhn et al., (2023):

ICTV Virus Taxonomy Profile: Mypoviridae, Journal of General Virology 2023, (in press)

Corresponding author: Yong-Zhen Zhang (张永振) (zhangyongzhen@fudan.edu.cn
Edited by: Jens H. Kuhn and Stuart G. Siddell
Posted: November 2023

Summary

Mypoviridae is a family of negative-sense RNA viruses with genomes of about 16.0 kb (Table 1.Mypoviridae). These viruses have been found in myriapods. The family includes a single genus with one species for one virus. The mypovirid genome consists of three monocistronic RNA segments with open reading frames (ORFs) that encode a nucleoprotein (NP), a glycoprotein (GP), and a large (L) protein containing an RNA-directed RNA polymerase (RdRP) domain.

Table 1. Mypoviridae. Characteristics of members of the family Mypoviridae

CharacteristicDescription
ExampleHúběi myriapoda virus 5 (S: KX884760; M: KX884759; L: KX884758), species Hubavirus myriapedis, genus Hubavirus
VirionUnknown
GenomeAbout 16.0 kb of trisegmented negative-sense RNA
ReplicationUnknown
TranslationUnknown
Host rangeMyriapods (centipedes/millipedes)
TaxonomyRealm Riboviria, kingdom Orthornavirae, phylum Negarnaviricota, class Ellioviricetes, order Bunyavirales;
the family includes the genus Hubavirus and the species Hubavirus myriapedis

Virion

Morphology

Unknown

Nucleic acid

Mypovirids have three segments (small [S], medium [M], and large [L]) of linear negative-sense RNA with a total length of about 16.0 kb (S segment: about 2.6 kb; M segment: about 3.5 kb; and L segment: about 9.9 kb) (Shi et al., 2016).

Genome organization and replication

Viruses of the family Mypoviridae have a trisegmented genome with three ORFs that encode a NP, a GP, and an L protein containing an RdRP domain (Shi et al., 2016) (Figure 1.Mypoviridae).

Mypoviridae genome
Figure 1.Mypoviridae. Genome organization, of Húběi myriapoda virus 5. ORFs are colored according to the predicted protein function (GP, glycoprotein gene; L, large protein gene; NP, nucleoprotein gene).

Biology

The only classified mypovirid, Húběi myriapoda virus 5 (HbMV5), was detected in unspecified myriapods (centipedes/millipedes) in China (Shi et al., 2016).

Unclassified mypovirids have been detected in dipteran insects (dolichopodid Heteropsilopus ingenuus (Erichson, 1842)) in Australia (Käfer et al., 2019) and in soil samples in China (Chen et al., 2022).

Derivation of names

Hubavirus: from Húběi myriapoda virus 5

Mypoviridae: from Húběi myriapoda virus 5

myriapedis: from host subphylum Myriapoda

Genus demarcation criteria

Not applicable (the family includes only a single genus).

Species demarcation criteria

Not applicable (the only genus includes only a single species).

Relationships within the family

Not applicable (the only genus includes only a single species).

Relationships with other taxa

Phylogenetic relationships of members of the family Mypoviridae are shown in Figure 2.Mypoviridae.

Mypoviridae phylogeny
Figure 2.Mypoviridae. Phylogenetic relationships of Húběi myriapoda virus 5. L protein sequences were aligned using MUSCLE and a maximum likelihood tree was produced using FastTree with default settings. Branches for members of other families are collapsed. Numbers at nodes indicate bootstrap support > 70%.

Viruses in the family Mypoviridae are most closely related to bunyaviral arenavirids, discoviridae, leishbuvirids, nairovirids, phenuivirids, and wupedevirids (Huang et al., 2019, Herath et al., 2020).

Virus nameAccession numberVirus abbreviationReference
dipteran mypo-related virus OKIAV322L: MT153408* (Käfer et al., 2019)

Virus names and virus abbreviations are not official ICTV designations.

* Incomplete genome