Table 1 - Confirmed HCV genotypes/subtypes (March 2022)
CONFIRMED HCV GENOTYPES/SUBTYPES
Genotype1 Locus/Isolate(s)2 Accession number(s) Reference(s)
Genotype 1
1a HPCPLYPRE, HPCCGAA M62321, M67463 (Choo et al., 1991; Inchauspe et al., 1991)
1b HPCJCG, HPCHUMR D90208, M58335 (Kato et al., 1990; Takamizawa et al., 1991)
1c HPCCGS, AY051292 D14853, AY051292 (Okamoto et al., 1994)(Guntaka et al. unpublished 2001)
1d QC103 KJ439768 (Lu et al., 2014)
1e 148636, QC172 KC248194, KJ439769 (Li et al., 2013), (Lu et al., 2014)
1g 1804, QC78 AM910652, KJ439770 (Bracho et al., 2008) (Lu et al., 2014)
1h EBW443, EBW9 KC248198, KC248199 (Li et al., 2013)
1i QC181 KJ439772 (Lu et al., 2014)
1j QC329 KJ439773 (Lu et al., 2014)
1k QC82 KJ439774 (Lu et al., 2014)
1l 136142, EBW424 KC248193, KC248197 (Li et al., 2013)
1m QC196, QC87 KJ439778, KJ439782 (Lu et al., 2014)
1n QC113, QC74 KJ439775, KJ439781 (Lu et al., 2014)
1o QC316, DE/17-0414 KJ439779, MH885469 (Lu et al., 2014; Wang et al., 2019)
Genotype 2
2a HPCPOLP, JFH-1 D00944, AB047639 (Kato et al., 2001; Okamoto et al., 1991)
2b HPCJ8G, JPUT971017 D10988, AB030907 (Murakami et al., 2001; Okamoto et al., 1992)
2c BEBE1 D50409 (Nakao et al., 1996)
2d QC259 JF735114 (Li et al., 2012)
2e QC64 JF735120 (Li et al., 2012)
2f ZS542, GZ98799 KC844042, KC844050 (Xu et al., 2013)
2i D54 DQ155561 (Noppornpanth et al., 2006)
2j C1799, QC232 HM777358 JF735113 (Sulbarán et al., 2010) (Li et al., 2012)
2k VAT96 AB031663 (Samokhvalov et al., 2000)
2l MRS89, PTR7904 KC197235, KC197240 (Jordier et al., 2013)
2m QC178, BID-G1314 JF735111, JX227967 (Li et al., 2012; Newman et al., 2013)
2q 963, 852 FN666428, FN666429 (Martró et al., 2011)
2r QC283 JF735115 (Li et al., 2012)
2t MRS40 KC197238 (Jordier et al., 2013)
2u QC182 JF735112 (Li et al., 2012)
2v 495-05 MW041295 (Rajhi et al., 2021)
Genotype 3
3a HPCEGS, HPCK3A D17763, D28917 (Sakamoto et al., 1994; Yamada et al., 1994)
3b HPCFG D49374 (Chayama et al., 1994)
3d NE274 KJ470619 (Li et al., 2014a)
3e NE145 KJ470618 (Li et al., 2014a)
3g BID-G1243, QC260 JX227954, JF735123 (Lu et al., 2013; Newman et al., 2013)
3h QC29 JF735121 (Lu et al., 2013)
3i IND-HCV, BID-G1244 FJ407092, JX227955 (Arankalle & Gupte 2008 unpublished)(Newman et al., 2013)
3k HPCJK049E1, QC105 D63821, JF735122 (Lu et al., 2013; Tokita et al., 1996)
Genotype 4
4a ED43 Y11604 (Chamberlain et al., 1997a)
4b QC264 FJ462435 (Li et al., 2009a)
4c QC381 FJ462436 (Li et al., 2009a)
4d 03-18, QC382 DQ418786, FJ462437 (Timm et al., 2007) (Li et al., 2009a)
4f IFBT88, PS6 EF589161, EU392175 (Hmaied et al., 2007),(Kuntzen et al., 2008)
4g QC193 FJ462432 (Li et al., 2009a)
4k PS3, QC383 EU392173, FJ462438 (Kuntzen et al., 2008), (Li et al., 2009a)
4l QC274 FJ839870 (Li et al., 2009a)
4m QC249 FJ462433 (Li et al., 2009a)
4n QC97 FJ462441 (Li et al., 2009a)
4o QC93 FJ462440 (Li et al., 2009a)
4p QC139 FJ462431 (Li et al., 2009a)
4q QC262 FJ462434 (Li et al., 2009a)
4r QC384 FJ462439 (Li et al., 2009a)
4s QC361 JF735136 (Lu et al., 2015)
4t QC155 FJ839869 (Li et al., 2009a)
4v CYHCV073, BID-G1248 HQ537009, JX227959 (Demetriou & Kostrikis, 2011), (Newman et al., 2013)
4w3 P212, P245 FJ025855, FJ025856 (Koletzki et al., 2009)
Genotype 5
5a EUH1480, SA134 Y13184 ,AF064490 (Bukh et al., 1998; Chamberlain et al., 1997b)
Genotype 6
6a EUHK2, 6a33 Y12083, AY859526 (Tokita et al., 1998)
6b Th580 D84262 (Tokita et al., 1998)
6c Th846 EF424629 (Lu et al., 2007a)
6d VN235 D84263 (Tokita et al., 1998)
6e GX004 DQ314805 (Li et al., 2006)
6f C-0044 DQ835760 (Lu et al., 2007b)
6g HPCJK046E2 D63822 (Tokita et al., 1996)
6h VN004 D84265 (Tokita et al., 1998)
6i Th602 DQ835770 (Lu et al., 2007b)
6j Th553 DQ835769 (Lu et al., 2007b)
6k VN405 D84264 (Tokita et al., 1998)
6l 537796 EF424628 (Lu et al., 2007a)
6m B4/92 DQ835767 (Lu et al., 2007b)
6n KM42, D86/93 DQ278894, DQ835768 (Lu et al., 2007b; Lu et al., 2006)
6o QC227 EF424627 (Lu et al., 2007a)
6p QC216 EF424626 (Lu et al., 2007a)
6q QC99 EF424625 (Lu et al., 2007a)
6r QC245 EU408328 (Li et al., 2009b)
6s QC66 EU408329 (Li et al., 2009b)
6t VT21, D49 EF632071, EU246939 (Lu et al., 2008; Noppornpanth et al., 2008)
6u D83 EU246940 (Noppornpanth et al., 2008)
6v NK46, KMN-02 EU158186, EU798760 (Lu et al., 2008), (Wang et al., 2009)
6w GZ52557, D140 DQ278892, EU643834 (Lee et al., 2010; Lu et al., 2006)
6xa5 DH012, DH028 EU408330, EU408332 (Xia et al., 2008)
6xb TV476, VN110 JX183552, KJ567645 (Li et al., 2014b; Wang et al., 2013)
6xc TV520 KJ567651 (Li et al., 2014b)
6xd L23, L347 KM252789, KM252790 (Li et al., 2015)
6xe DH027, KM98 JX183557, KM252792 (Li et al., 2015; Wang et al., 2013)
6xf VN214, TV469 KJ567647, KJ567646 (Li et al., 2014b)
6xg KS27, KS81 MH492360, MH492361 (Ye et al., 2019)
6xh 1350-1 MG879000 (Wu et al., 2018)
6xi KM35, YNKH261 JX183549, MZ504973 (Wang et al., 2013; Yue et al., 2020)
6xj KM45, YNKH298a DQ2788916, MZ171127 (Lu et al., 2006), (Jia et al., 2021)
Genotype 7
7a QC69 EF108306 (Murphy et al., 2015)
7b BAK1 KX092342 (Salmona et al., 2016)
Genotype 8
8a GT8-1 MH590698 (Borgia et al., 2018)
An alignment of representatives of these genotypes / subtypes is available at http://hcv.lanl.gov/content/sequence/NEWALIGN/align.html
1 Consensus proposed genotype/subtype names. Where multiple sequences of a HCV genotype are available, two sequences have been listed, prioritised by (a) publication date or (b) submission date when unpublished.
2 Locus (or isolate name if locus is the same as the accession number).
3 Previously described as 4b, (Koletzki et al., 2009; Nakano et al., 2012)
4 Sequence obtained from acute phase plasma of a chimpanzee experimentally infected with (human-derived) isolate SA13.
5 Previously described as 6u (Xia et al., 2008).
6 Previously described as 6k (Lu et al., 2006)
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